Dictyostelium discoideum: A Model System to Study Autophagy Mediated Life Extension
نویسندگان
چکیده
Autophagy is a major catabolic process in eukaryotes that help degrade and recycle macromolecules and organelles. Recent evidences suggest autophagy to mediate cytoprotection and also help increase longevity. It acts as a central regulatory mechanism for aging/longevity in diverse eukaryotic species. In the present study we have exploited the lower eukaryotic model organism, Dictyostelium discoideum to study longevity, which could use autophagy as a major mechanism for increasing lifespan. This organism is unique as it follows a developmental programmed cell death by autophagy that is independent of caspases. It could be a beneficial organism to delineate the mechanism of increased longevity that follows autophagy.
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